Factors associated with microsporidial and cryptosporidial diarrhea in HIV infected patients.

Cryptosporidium and microsporidia are increasingly recognized as important agents of chronic diarrhea in human immunodeficiency virus (HIV) infected patients. These protozoa present clinical and biological similarities but coinfection with these two parasites seems uncommon in a population of diarrheic HIV infected patients in the Paris area (France), a comparison study was performed in order to clarify epidemiological differences between these protozoa. From November 1993 to December 1994, 26 microsporidial infected patients were compared to 28 cryptosporidial patients for various factors. Results of a multivariate logistic regression analysis showed that trips to tropical countries remained strongly associated with microsporidic compared with Cryptosporidium adjusted odds ratio [OR] = 4.6, 95% confidence interval [CI] 1.1-19.5). Thus, as compared with cryptosporidiosis, specific epidemiological factors could be associated with microsporidial transmission in tropical countries.